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@jemoka / Jemoka Knowledge Base / raw/concept/kbhimmunogen_design.md
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--- title: "Immunogen Design" source: https://www.jemoka.com/posts/kbhimmunogen_design/ --- Using a bunch of signals to create a 3d representation of the system features cyro-EM x-ray tomo glynomics/libidomics genetics studying large-scale viron surface protein behavior using MD “we are so biased by what we can see experimentally, so do MD” “breathing” motion proteins of specific virons “breath”: oning and closing an entire backbone group; this is not yet quantified in physical modeling when its open, the “breathing open” motion causes the virus to be vunerable so some antibodies jam into the open position “head tilting” motion when its tilted, there is an epitope that becomes exposed this is a site that’s possible for introduction of what’s needed overall architecture use conventional MD discover regions of instability (see above for examples) for possible binding surfaces bam inhibition! maybe at some point run a cyro-EM to experimentally run some