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@jemoka / Jemoka Knowledge Base / raw/concept/kbhrosettafold2.md
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--- title: "RoseTTAFold2" source: https://www.jemoka.com/posts/kbhrosettafold2/ --- RoseTTAFold2 is a three-track folding tool, which also handles multimer! inputs: amino acid sequence + CHEMICAL structure (WOAH! how?) “RF2 all-atom embedding” fold! The model does really well! application: de-novo luciferase design come up with the correct shaped scaffolds use old Rosetta to jam a residue sequence into the scaffold refold application: RoseTTAFold2 in-painting Train the model to recover the missing bits of sequence from the overall structure (i.e. training backwards), and