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@jemoka / Jemoka Knowledge Base / wiki/concepts/rfdiffusion.md
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--- title: "RFDiffusion" type: concept related: [Rosettafold2, Rfdiffusion] source: https://www.jemoka.com/posts/kbhrfdiffusion/ confidence: high status: active --- Starting with random residue noise: coordinates + backbones Diffusion happens: train like diffusion, with the goal of increasing binding affinities Eventually resolves to valid protein structures given the binding environments Basically, start with only the desired substraight, and the diffuse the sequence around that small sequence with the goal of higher affinity binding: i.e. allow only the binding site to stay and regenerating the rest. RFDiffusion is available starting THIS WEEK! advantages over RoseTTAFold2 inpainting The starting point is random for diffusion, so if you do it multiple times you will get new results instead of the same thing.